A total of three protesters have reportedly died in Friday clashes with security, as protests grew violent.
Two members of the Muslim Brotherhood were killed in a shoot out with security forces in the Nile Delta north of Cairo, the state news agency reported on Friday.
The MENA news agency said they were part of a group that had opened fire on police on a road between the cities of Tanta and al-Mahalla al-Kubra in the Nile Delta province of Gharbiya.
They had also tried to set ablaze a traffic police checkpoint, according to the report, which said a third assailant had been arrested while others got away.
State TV also quoted the Ministry of Health as saying that one person was killed during clashes between police and Muslim Brotherhood loyalists in Soyouf, Alexandria.
Damietta security chief Abu Bakr al-Hadidy said four Brotherhood loyalists were arrested during a 60-people rally following the Friday prayer with “instigative” signs. He added that the security situation in the province remains stable.
At al-Azhar University hostel in Cairo, violent encounters broke put between police and pro-Morsy students who marched across the hostel chanting anti-police and army slogans
Students had blocked Mostafa al-Nahhas Street outside the hostel before security attempted to disperse their protests with tear gas.
In Giza, security fired tear gas towards a march by Mohamed Morsy supporters in Mohandiseen who chanted slogans against security forces and Sisi. Women and children were at the forefront of demonstrators.
A march by Sisi backers was also on its way to the area.
Security and Brotherhood backers exchanged tear gas and fireworks after demonstrators had set on their protests from al-Rahma mosque to denounce Sisi's presidency nomination.
In Minya, Osama Metwally, the province's security chief, told Al-Masry Al-Youm that security had dispersed three small-scale Brotherhood marches where demonstrators possessed fire bottles and chanted against police and the army.
In Dar al-Salam, south of Cairo, the Interior Ministry's media official said forces apprehended two demonstrators with BB guns and bullets following a march.
Attacks on police and soldiers have become commonplace since the army deposed Mohamed Morsy of the Muslim Brotherhood last July following mass protests against his rule.
The state has declared the Brotherhood a terrorist group. The group's leaders say it remains committed to peaceful activism.
Former army chief Abdel Fattah al-Sisi said fighting militancy was one of his priorities when he announced his candidacy for a presidential election that he is expected to win easily next month.