Nasr Road has been re-opened to traffic after being blocked by a demonstration by university students on Saturday morning.
Students were protesting in favour of the Muslim Brotherhood and Islamist President Mohamed Morsy.
Male and female students from Al-Azhar University demonstrated on the first day of school, blocking the road. Disputes between protesters and motorists trying to pass broke out.
Students wore T-shirts with the four-fingered Rabaa symbol, a reference to the pro-Morsy sit-in at nearby Rabaa al-Adaweya which was violently dispersed by security forces on 14 August.
They chanted slogans denouncing Defense Minister Abdel Fattah al-Sisi and Al-Azhar Grand Sheikh Ahmed al-Tayyeb.
Azhar University had earlier decided to postpone the beginning of the school year for a second time, starting on 19 October instead of 5 October, because of the security situation in Cairo and Egypt.
Edited translation from Al-Masry Al-Youm