Alexandria schools have seen 249 cases of mumps and chickenpox this month alone, according to Mohsen George, the Alexandria Education Department's general director of executive affairs.
This brings the total number of infections this year to 489.
George added that the infected students were isolated from the rest of the student body to prevent the spread of the diseases.
Education departments and schools were alerted to the heightened state of emergency.
Efforts are also being coordinated with the Health Ministry to appoint doctors to handle the cases, which have been on the rise since the school year started in September.
The Health Ministry earlier said that it could control the problem and prevent any interruption to students' education.
However, Al-Masry Al-Youm reported last month that classes have been suspended for two weeks at a school in Qalyubiya after 60 students contracted mumps.
Edited translation from Al-Masry Al-Youm
Correction: This article has been changed to specify the correct disease is chickenpox.